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August 1991

Mizuo Phenomenon in X-linked RetinoschisisPathogenesis of the Mizuo Phenomenon

Arch Ophthalmol. 1991;109(8):1104-1108. doi:10.1001/archopht.1991.01080080064029

• Four unrelated males with X-linked retinoschisis and a golden fundus reflex had Mizuo-Nakamura phenomenon, which, to our knowledge, has been described only in Oguchi's disease and X-linked cone dystrophy. These findings, together with experimental observations and data from the literature, led us to hypothesize that the Mizuo-Nakamura phenomenon is caused by an excess of extracellular potassium in the retina as a result of a decreased potassium scavenging capacity of retinal Müller cells.