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September 1991

Transferrin Receptor Expression by Retinal Pigment Epithelial Cells in Proliferative Vitreoretinopathy-Reply

Author Affiliations

Durham, NC
San Diego, Calif
Emeryville, Calif

Arch Ophthalmol. 1991;109(9):1196. doi:10.1001/archopht.1991.01080090017008

In Reply.  —We were pleased to see that the data collected by Baudouin et al show transferrin receptors on retinal pigment epithelial cells from subretinal and vitreous fluids in patients with proliferative vitreoretinopathy; thus, these cells are targets for transferrin receptor-specific immunotoxin. Weller et al1 have similarly shown that transferrin receptors are present on cells in PVR membranes, which are additional targets for this agent. These data support the idea that immunotoxins directed against markers of cell proliferation will be useful in treating patients with PVR. Normal, nonproliferating ocular tissues are likely to contain transferrin receptors; therefore, the immunotoxin should selectively inhibit actively dividing cells. We found that the immunotoxin selectively inhibited proliferating, and not quiescent, cells in vitro.2,3 Recently, Davis et al4 reported that transferrin receptors were present in increased numbers on proliferating retinal pigment epithelial cells compared with nonproliferating cells; these data suggest that the

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