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October 1991

New Trends in Lipid Mediators Research, vol 5, Lipid Mediators in Eye Inflammation

Author Affiliations

Boston, Mass

Arch Ophthalmol. 1991;109(10):1361. doi:10.1001/archopht.1991.01080100041026

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Metabolites of lipids are involved in a broad array of biological activities. They are crucial in physiologic responses, including cell signal transduction, and in pathologic processes of the inflammatory response. The roles of phospholipase A2, leukotrienes, prostaglandins, platelet-activating factor, and other biologically active lipid-derived mediators in ocular inflammation are discussed in this slim volume.

Many researchers are studying the role of lipid mediators in ocular inflammation and efforts continue to develop pharmacologic means of influencing the effects of these mediators. The time is right for a text summarizing our current understanding but, unfortunately, this monograph is only partially successful.

"... of most interest to those conducting research on inflammation and pharmacology.... "

Twenty-six authors contributed to the 12 chapters that vary from individual experimental projects to literature reviews. Some chapters concentrate on basic cell biology and biochemistry, while others describe clinical responses in animal models.

An effort was made to include

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