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February 1992

Superficial Granular Corneal Dystrophy With Amyloid Deposits

Author Affiliations

Chicago, Ill

Arch Ophthalmol. 1992;110(2):175-176. doi:10.1001/archopht.1992.01080140025015

Granular corneal dystrophy with clinically undetected concomitant amyloid deposition has been previously described.1,2 We describe the association of corneal amyloid deposits in the superficial variant of granular dystrophy with its own distinctive features.

Report of a Case.  —An 8-year-old Palestinian boy presented with complaints of difficulty reading and glare of 3 years' duration. The ocular history was unremarkable. However, there was history of consanguinity in the family.On ocular examination, the patient's visual acuity was 20/100 OD and 20/200 OS. Slitlamp examination revealed discrete, grayish-white crumblike opacities in the anterior one fourth of the corneal stroma, with clear areas between the deposits (Fig 1). Rare, deep lesions were also noted. The remaining ocular examination results were unremarkable.Of the family members examined, one paternal uncle had subtle corneal changes similar to the patient's but with no symptoms. The parents and three younger siblings did not show evidence of disease.

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