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April 1992

Treatment of Endophthalmitis

Author Affiliations

Chattanooga, Tenn

Arch Ophthalmol. 1992;110(4):449. doi:10.1001/archopht.1992.01080160027010

To the Editor.  —I read with interest the report by Pfeifer et al1 in the December 1991 issue regarding endogenous Pseudallescheria boydii endophthalmitis. Has an error been made in the doses for intraocular antibiotics in the case reports? Doses of 5 mg of intravitreal amphotericin and 750 mg of vancomycin are mentioned in the first case; 750 mg of vancomycin is also described as an intravitreal dose in the second case. These doses are substantially larger than those considered safe by most retinologists treating endophthalmitis by intravitreal injection.

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