Metastatic carcinoma is known to be the most common intraocular malignant tumor, and primary breast carcinoma is the tumor most frequently responsible for choroidal metastases.1 Metastatic tumor shrinkage in response to chemotherapy alone has been only occasionally reported. Consequently, radiotherapy is usually the first-line treatment for choroidal metastases. We used chemotherapy to treat a woman with breast cancer and a high estrogen-receptor titer who presented with decreased visual acuity secondary to a choroidal metastasis. The result was complete resolution of the lesion.
Report of a Case.
—A 52-year-old postmenopausal black woman with a history of metastatic left breast cancer to bone and lung was seen in consultation for decreased visual acuity in the right eye. Two and one half years before consultation she had been diagnosed with left infiltrative ductal breast cancer and had undergone a left modified radical mastectomy. Her laboratory results revealed the following: high estrogen receptor
Logani S, Gomez H, Jampol LM. Resolution of Choroidal Metastasis in Breast Cancer With High Estrogen Receptors. Arch Ophthalmol. 1992;110(4):451–452. doi:10.1001/archopht.1992.01080160029012