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May 1992

Effect of Flurbiprofen on the Reduction of Intraocular Pressure After Administration of 1% Apraclonidine in Patients With Glaucoma

Arch Ophthalmol. 1992;110(5):598-599. doi:10.1001/archopht.1992.01080170020009

To the Editor.  —We read with great interest the two recent articles demonstrating that flurbiprofen (Ocufen) applied topically does not affect the reduction of intraocular pressure (IOP)1 or aqueous flow2 produced by apraclonidine (Iopidine) in normotensive volunteers. These studies were conducted as a result of our previous study demonstrating that flurbiprofen blocks the hypotensive effect of apraclonidine in both normotensive and laser-induced glaucomatous monkey eyes. Herein, we detail a clinical study, previously reported in part,3,4 evaluating for the first time the effect of flurbiprofen on the reduction of IOP after apraclonidine administration in patients with ocular hypertension and glaucoma.Entry criteria for the study included an average IOP without treatment of at least 20 mm Hg in both eyes, visual acuity of at least 20/100 OU, open anterior chamber angles, minimal visual field loss, no evidence of secondary glaucoma, and no previous ocular surgery or laser procedures.