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May 1992

The Correlation of Visual Function With Posterior Retinal Structure in Severe Retinopathy of Prematurity

Author Affiliations

From the Department of Ophthalmology, Children's National Medical Center, and The George Washington University School of Medicine and Health Sciences, Washington, DC (Dr Gilbert); the Departments of Psychiatry and Psychology, University of Pittsburgh (Pa) (Dr Dobson); the Division of Pediatric Ophthalmology, Children's Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania, Philadelphia (Dr Quinn); the Department of Ophthalmology, Children's Hospital of Buffalo, University at Buffalo (NY) (Dr Reynolds); the University of Texas Health Science Center at Houston (Tex), School of Public Health (Ms Tung); and the Bascom Palmer Eye Institute, Miami, Fla (Dr Flynn).

Arch Ophthalmol. 1992;110(5):625-631. doi:10.1001/archopht.1992.01080170047022

• The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity previously reported reduced incidence of both poor structural and functional outcomes after cryotherapy. We compared the results in 304 eyes of patients in the randomized portion of the trial in whom both structural and functional assessments were performed 12 months after randomization. Two hundred fifty-five eyes (83.9%) had concordant outcomes: 153 eyes had favorable structural and functional outcomes and 102 eyes had unfavorable structural and functional outcomes. Twenty-nine eyes (9.5%) had discordant outcomes: 20 eyes had favorable structural and unfavorable functional outcomes and nine eyes had unfavorable structural and favorable functional outcomes. The small number of discordant outcomes could generally be accounted for by three factors: (1) retinal abnormalities beyond those considered in the photographic grading system (12 eyes), (2) nonretinal visual pathway disease (five eyes), or (3) false-positive and false-negative results in the measurement systems used to evaluate structure and function (five eyes). In 20 eyes (6.6%), photographs could not be graded or the visual acuity was untestable. We conclude that the appearance of the posterior pole of the eye correlates well with grating acuity in the 12-month-old infant with a history of severe retinopathy of prematurity.

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