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June 1992

Surgical Management of Advanced Ocular Adnexal Amyloidosis

Author Affiliations

From the Department of Ophthalmology, Cullen Eye Institute, Houston, Tex (Drs Patrinely and Koch), and the Division of Plastic Surgery, Baylor College of Medicine, Houston (Dr Koch).

Arch Ophthalmol. 1992;110(6):882-885. doi:10.1001/archopht.1992.01080180154045

• Ocular adnexal amyloidosis is characterized by amyloid deposition within the deep connective tissue layers of the eyelids, conjunctiva, and anterior orbit. Management of advanced cases has traditionally been unsatisfactory, with either no surgery offered because of fear of hemorrhage or an en bloc resection performed of the entire involved area. We present two cases of advanced periorbital amyloidosis successfully managed by preserving the anatomic planes of the eyelids and meticulously debulking the deposits with a spooned curette. Lax eyelid tendons and aponeuroses were simultaneously repaired, and no sacrifice of eyelid tissues was necessary. One patient remained asymptomatic for 2 years after surgery before developing early reaccumulation in the lower eyelids. The other patient required additional eyelid debulking and ptosis revision 8 months after surgery, but was in stable condition at follow-up 2 years after surgery. This technique offers safe, easily repeatable, nondestructive treatment for advanced periocular amyloidosis.

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