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November 1992

Corneal Endothelial Toxicity of DexSol Corneal Storage Medium Supplemented With Povidone-Iodine

Arch Ophthalmol. 1992;110(11):1519-1520. doi:10.1001/archopht.1992.01080230017007

To the Editor.  —Bacterial endophthalmitis is a dreaded and often visually devastating complication of penetrating keratoplasty. Current methods to achieve antisepsis of donor corneal tissue, such as the addition of gentamicin to the corneal storage media, have had a suboptimal effect. At the storage temperature of 4°C gentamicin provides only limited coverage against gram-positive bacteria, such as Streptococcus pneumoniae.1 In comparison with antibiotics, povidoneiodine is a broad-spectrum disinfectant with rapid activity against bacteria, fungi, viruses, protozoa, and spores.2 We therefore chose to investigate the antimicrobial spectrum and corneal endothelial toxicity of povidone-iodine in DexSol corneal storage medium (Chiron, Irvine, Calif).The corneal endothelial toxicity of DexSol supplemented with gentamicin (100 μg/mL) was compared with that of DexSol supplemented with either 5%, 1%, or 0.1% povidoneiodine without gentamicin using paired human donor corneas. For each corneal pair, one cornea was placed in standard DexSol with gentamicin, and the other

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