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December 1992

Successful Treatment of Gram-negative Endophthalmitis With Intravitreous Ceftazidime

Arch Ophthalmol. 1992;110(12):1686. doi:10.1001/archopht.1992.01080240024015

We present the first report, to our knowledge, of a case of gram-negative endophthalmitis (Morganella morgagnii) successfully treated by intravitreous injection of ceftazidime after vitrectomy.

Report of a Case.  —A 76-year-old white hypertensive woman with age-related macular degeneration and Fuchs' dystrophy had undergone a prior triple procedure (penetrating keratoplasty, cataract extraction, and posterior chamber intraocular lens implantation) on her left eye in October 1990; in May 1991, the patient's best-corrected visual acuity was 4/200 OS due to macular degeneration. One week after a YAG capsulotomy in the left eye in January 1992, she underwent repair of a penetrating keratoplasty wound dehiscence. She received topical gentamicin sulfate and erythromycin for 1 week after surgery. Three weeks later she developed pain with decreased vision in her left eye. She returned to The Wilmer Institute, where a diagnosis of endophthalmitis was made.Visual acuity was 20/70 OD and hand motions OS. The left