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January 1993

Immune-Related Disease and Normal-Tension Glaucoma-Reply

Arch Ophthalmol. 1993;111(1):23-24. doi:10.1001/archopht.1993.01090010024014

In Reply.  —We are grateful to Dana and Wilensky and Hejkal and Yablonski for their careful and critical reading of our article. In designing our case-control study, we viewed the population as a continuum of people with varying degrees of susceptibility to damage from intraocular pressure. Those with unknown optic nerve susceptibility factors in high degree would develop NTG because their eyes are sensitive even to the normal level of intraocular pressure. In the middle ground are those who have high-tension glaucoma, having a more moderate amount of susceptibility factors, enough to make moderate elevation of the intraocular pressure harmful. Finally, at the other end of the spectrum are those ocular hypertensives so lacking in these susceptibility factors that they do not suffer damage even when challenged by elevated intraocular pressure. When looking for an explanation as to why some individuals are at one end of the spectrum and others