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February 1993

Peripseudophakic Membrane: Pathologic Features

Author Affiliations

From the Cornea Service (Drs Pavilack, Foster, and Kowal), Uveitis and Immunology Service (Dr Foster and Mr Dutt), and Pathology Service (Dr Albert), Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, and the Hilles Immunology Laboratory, Boston.

Arch Ophthalmol. 1993;111(2):240-244. doi:10.1001/archopht.1993.01090020094031

• A 70-year-old woman underwent anterior segment reconstruction with repeated penetrating keratoplasty for visual rehabilitation. On removal of the failed keratoplasty button, the posterior chamber intraocular lens was found to be encased in a dense fibrous membrane that almost totally obliterated the anterior and posterior chambers of the eye. Anterior segment reconstruction included excision of the fibrous membrane, removal of the intraocular lens, iridoplasty, gonioplasty, anterior vitrectomy, and repeated penetrating keratoplasty. Recognition of fibrous tissue that extended through each of the four positioning holes of the optic of the lens implant and its transection was essential in avoiding complications during removal of the intraocular lens. Histopathologic and ultrastructural examination of the excised membrane revealed areas of metaplastic lens epithelium and fibrous scar tissue. This study, using immunofluorescence, is the first, to our knowledge, to characterize the specific collagenous components of a peripseudophakic membrane.

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