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March 1993

Macular Pigment Epitheliopathy in Retinopathy of Prematurity-Reply

Arch Ophthalmol. 1993;111(3):298. doi:10.1001/archopht.1993.01090030016004

In Reply.  —For some time, physicians have been intrigued concerning the ophthalmoscopic phenomenon of retinal pigment epithelium abnormality associated with regressed ROP.1 This abnormality is manifest by varying degrees of loss or increase of pigmentation of the pigmented epithelium, may appear in any subretinal location, and may sometimes involve complete atrophy of the choroid. Dr Hindle, in his letter, claims precedent for the name macular pigment epitheliopathy, assigned by him in publications as early as 1982, to such alterations. His assertions to this effect and supporting references that also posit causes speak for themselves.The pathogenesis of such phenomena and their effects on visual function remain incompletely understood. Our data confirm this. Our choice of nomenclature, retinal pigment epithelial scarring, is taken from the classification employed in the macular photographic scoring protocol used in the CRYO-ROP study,2 which in turn is based on the International Classification of ROP