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April 1993

Repair and Replacement to Restore Sight: Report From the Panel on Ganglion Cell/Connectivity

Author Affiliations

From the Department of Molecular and Cell Biology, University of California, Berkeley (Dr Shatz) and the Molecular Neurobiology Laboratory, Salk Institute, San Diego, Calif (Dr O'Leary). Dr Steinberg, editor for publication of this article, is a consultant for Regeneron Pharmaceuticals Inc, Tarrytown, NY. For a list of the members of the Ganglion Cell/Connectivity Panel, see end of this article.

Arch Ophthalmol. 1993;111(4):472-477. doi:10.1001/archopht.1993.01090040064031

A major goal of research on the visual system is to understand processes that promote repair and regeneration of central visual connections following disease or trauma. A number of distinct clinical conditions lead to the destruction or degeneration of retinal ganglion cells that, in turn, can result in permanent blindness. Among the major causes of ganglion cell loss are glaucoma, diabetic retinopathy, demyelinating diseases, tumors, optic neuropathy, ischemia, and traumatic injury. It is first desirable to prevent or retard the progress of neuronal injury and death in these diseases, but once connections to central visual targets are lost, the only way to restore sight is to promote the regeneration of ganglion cell connections. Recent advances have shown that this is an area of great promise for future treatment. It had long been thought that the regeneration of optic projections was not possible in the central nervous system (CNS), but findings

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