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April 1993

Anti-inflammatory Effect of Diclofenac Drops After Argon Laser Trabeculoplasty

Author Affiliations

From the Department of Ophthalmology, Hôpital Jules Gonin, University of Lausanne (Switzerland). The authors do not have any commercial or proprietary interest in the diclofenac sodium drops.

Arch Ophthalmol. 1993;111(4):481-483. doi:10.1001/archopht.1993.01090040073033

• Using a laser flare-cell meter, the anti-inflammatory effect of diclofenac sodium drops was evaluated after argon laser trabeculoplasty in a double-masked placebo-controlled study. Fifty-three eyes with pseudoexfoliative (43 eyes) or pigmentary glaucoma (10 eyes) were randomly assigned to treatment (n=27) or placebo (n=26) groups. Diclofenac (0.1%) or placebo drops were administered once before and after trabeculoplasty and then four times daily for a total of 4 days. Visual acuity, intraocular pressure, and anterior chamber flare, measured with the laser flare-cell meter, were evaluated before trabeculoplasty, 3 and 6 hours after trabeculoplasty, and 1, 2, 4, 7, and 14 days after trabeculoplasty. Flare increase after argon laser trabeculoplasty was completely blocked by 0.1% topical diclofenac and the mean of maximal flare increases was reduced significantly in the diclofenac group. Therefore, 0.1% diclofenac drops represent a very efficient antiinflammatory therapy after argon laser trabeculoplasty.

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