• We report the histopathological findings of the anterior cornea from a patient with skin biopsy-proven epidermolysis bullosa simplex. As seen with light microscopy, the cornea had a fibrocellular pannus deep to a thickened epithelial basement membrane. Transmission electron microscopy of the anterior cornea demonstrated a nonhomogeneous basal epithelial layer with abnormal attachment complexes to an irregular, multilaminar basement membrane. The findings of transmission electron microscopy of the bulbar conjunctiva were normal.
Adamis AP, Schein OD, Kenyon KR. Anterior Corneal Disease of Epidermolysis Bullosa Simplex. Arch Ophthalmol. 1993;111(4):499–502. doi:10.1001/archopht.1993.01090040091039
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