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May 1993

Intracameral Tissue Plasminogen Activator in Neovascular Glaucoma

Author Affiliations

Detroit, Mich

Arch Ophthalmol. 1993;111(5):586. doi:10.1001/archopht.1993.01090050020014

Recent reports have documented the efficacy of tissue plasminogen activator in promoting fistula reformation following trabeculectomy1,2 and relieving fibrin-induced pupillary block after retinal procedures.3 We present herein a case in which we successfully used intracameral tissue plasminogen activator in a diabetic patient with neovascular glaucoma who developed a severe anterior chamber fibrin reaction following trabeculectomy with adjunctive mitomycin C.

Report of a Case.  —A 40-year-old black woman with moderate background diabetic retinopathy underwent an uncomplicated cataract extraction using phacoemulsification with implantation of a posterior chamber intraocular lens in the right eye. The postoperative visual acuity was 20/20. Four months after surgery the patient presented with rubeosis iridis, a 5% hyphema, and counting fingers visual acuity. Immediate panretinal photocoagulation was performed.The patient remained in stable condition until 10 months later when she presented with a Serratia marcescens corneal ulcer and hypopyon in the right eye for which she

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