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June 1993

Supplemental Vitamin A Retards Loss of ERG Amplitude in Retinitis Pigmentosa

Arch Ophthalmol. 1993;111(6):751-754. doi:10.1001/archopht.1993.01090060039019

These words conclude the report of a clinical trial published in this issue of the Archives that was designed to evaluate the effects of nutritional supplements of vitamins A and E on the natural course of retinitis pigmentosa. This study is a tour de force in experimental design, execution, and statistical analysis. The investigators deserve congratulations on the successful completion of this ambitious, rigorous, and interesting study.

See also pp 754 and 761.

Retinitis pigmentosa can be a devastating disease for the patient who suffers night blindness, progressive visual field loss, and eventually loss of central vision. There is no cure for retinitis pigmentosa, and patients are in constant search of hope. Therefore, when interpreting the intriguing results of this clinical trial, it is important to use caution and to avoid drawing unwarranted conclusions that could lead to unreasonable expectations by patients. Despite our admiration of the design and execution

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