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June 1993

Pharmacologic Induction of Posterior Vitreous Detachment in the Rabbit

Arch Ophthalmol. 1993;111(6):849-854. doi:10.1001/archopht.1993.01090060139038

• Objective.  —To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.

Methods.  —We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.

Results.  —In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.

Conclusion.  —Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.