[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
August 1993

Topical Diclofenac Reduces Pain Following Photorefractive Keratectomy

Author Affiliations

Louisville, Ky
Minneapolis, Minn

Arch Ophthalmol. 1993;111(8):1022. doi:10.1001/archopht.1993.01090080016002

Severe postoperative pain has been a significant complication of excimer laser photorefractive keratectomy (PRK). We report herein the dramatic effect of topical diclofenac sodium (Voltaren Ophthalmic) for relieving patient discomfort following PRK.

We performed a retrospective analysis of 20 consecutive patients who had undergone bilateral PRK for myopia as part of a phase III US Food and Drug Administration study (the second eye was operated on 6 months after the first). Initially treated eyes were generally the more myopic of the two. Following PRK using topical anesthesia, one drop each of tobramycin, 0.25% scopolamine, and 0.1% fluorometholone were administered and a disposable contact lens was placed on the eye. The patients were instructed to use the tobramycin four times a day and the 0.1% fluorometholone every 2 hours while awake. The regimen was identical in the second eye with the exception ofthe addition of 0.1% diclofenac four times a day.