To determine whether intraocular administration of tissue plasminogen activator (tPA) speeds clearance of inflammatory debris or prevents fibroproliferative complications in an animal model of endophthalmitis.
Aphakic rabbits were given an intraocular dose of Staphylococcus epidermidis organisms known to cause moderate inflammation and to self-sterilize. They were then randomized to receive either tPA or saline injections 2 and 3 days after inoculation. All eyes were graded by one masked clinician seven times, 1 to 28 days after infection. Vitreous samples from selected eyes were cultured.
Treated and control eyes were found to have no significant difference in inflammatory scores. Although the eyes treated with tPA had more retinal detachments and more positive cultures than control eyes, these numbers were not statistically significant (P=.44 to.71).
Fibrinolysis with intraocular tPA does not accelerate clearance of inflammation nor decrease fibroproliferative complications in this animal model of endophthalmitis.
Ryan EH, Mizener JB. Tissue Plasminogen Activator and Staphylococcus epidermidis Endophthalmitis. Arch Ophthalmol. 1993;111(8):1117–1122. doi:10.1001/archopht.1993.01090080113026