Imaging of the angioarchitecture of normal and abnormal choriocapillaris such as choroidal neovascularization has been a difficult task. Fluorescein angiography cannot delineate the choroidal circulation behind the relatively opaque retinal pigment epithelium. In recent years, imaging of the choroidal circulation immediately following intravenous injection of indocyanine green (ICG) has been an innovative method to explore the choroidal circulation.1,2 However, weak fluorescence of ICG and poor understanding of the binding property of the dye with human serum proteins have resulted in poor imaging of the choriocapillaris. We recently observed that the binding of ICG with human serum albumin (HSA) took 600 seconds to reach equilibrium and that the ICG-HSA complex was highly fluorescent at near-infrared wavelength. Based on this observation, we performed angiography with the dye dissolved in autologous serum prior to intravenous injection to take advantage of the highly fluorescent property of the ICG-HSA complex. This method provided us
Yoneya S, Noyori K. Improved Visualization of the Choroidal Circulation With Indocyanine Green Angiography. Arch Ophthalmol. 1993;111(9):1165–1166. doi:10.1001/archopht.1993.01090090015002
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