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October 1993

Stromal Keratitis Associated With Epstein-Barr Virus Infection in a Young Child

Author Affiliations

Atlanta, Ga; Greenwich, Conn; Minneapolis, Minn

Arch Ophthalmol. 1993;111(10):1323-1324. doi:10.1001/archopht.1993.01090100029016

Epstein-Barr virus infection has been associated with stromal keratitis in adolescents and young adults.1 In low-socioeconomic conditions, systemic infection with Epstein-Barr virus is common in early childhood, with 50% to 85% of children acquiring serologic evidence of infection by age 4 years. Children infected with Epstein-Barr virus are usually asymptomatic and do not have the classic signs of infectious mononucleosis, such as fever, pharyngitis, lymphadenopathy, hepatomegaly, or splenomegaly.2 To date, the youngest patient described with keratitis associated with Epstein-Barr virus infection was a 9-year-old boy.1 We report herein a case of stromal keratitis in a 21-month-old child with serologic evidence of acute Epstein-Barr virus infection.

Report of a Case.  In July 1991, a 21-month-old boy was referred to the University of Iowa Hospitals and Clinics, Iowa City, with a 2-week history of redness and tearing in both eyes. The conjunctiva was moderately hyperemic in both eyes. Examination