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January 1994

Oral Imipramine and Acute Angle Closure Glaucoma

Author Affiliations

From the Departments of Ophthalmology, the New York (NY) Eye and Ear Infirmary (Dr Ritch), Northwestern University School of Medicine, Chicago, Ill (Dr Krupin), University of Arkansas for Medical Sciences, Little Rock, Ark (Dr Henry), and St Vincent's Medical Center, Los Angeles, Calif (Dr Kurata). The authors have no financial interest in any product discussed in this article.

Arch Ophthalmol. 1994;112(1):67-68. doi:10.1001/archopht.1994.01090130077021

Objective:  To document acute angle closure glaucoma temporally related to ingestion of oral imipramine hydrochloride.

Patients:  Four patients with narrow angles received routinely prescribed doses of imipramine that triggered acute angle closure glaucoma.

Outcome:  Laser iridotomy was successful in all patients.

Conclusions:  Psychoactive drugs should be prescribed cautiously in patients with known narrow angles and should be monitored by an ophthalmologist.

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