Two recent articles in reference to the steroid treatment trial of optic neuritis raised some questions in my mind. The first was by Beck et al1 in the New England Journal of Medicine and the second related article, which reported on data collected as the first study progressed, was published in the June 1993 issue of the Archives.2
The first study enrolled 457 patients with acute optic neuritis. The data that were presented were valuable in expanding our understanding of optic neuritis. It seemed that the efficacy of both treatment groups was low, but that a significantly higher number of patients treated only with oral prednisone had recurrent optic neuritis. The other two groups were treated with intravenous methylprednisolone followed by oral prednisone and placebo only. The last paragraph of the article suggests that "... there is no role for oral prednisone alone in the treatment of patients with
Wilson WB. How Much Should We Editorialize? Arch Ophthalmol. 1994;112(3):298–299. doi:10.1001/archopht.1994.01090150028004
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