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March 1994

Correlation of Asymmetry of Visual Field Loss With Optic Disc Topography in Normal-Tension Glaucoma

Author Affiliations

From the Department of Ophthalmology, Helsinki (Finland) University Central Hospital, University of Helsinki (Drs Nyman and Raitta), and the Department of Ophthalmology, Gifu (Japan) University School of Medicine (Drs Tomita and Kawamura). None of the authors has any financial, commercial, or proprietary interest in the instruments mentioned in the study.

Arch Ophthalmol. 1994;112(3):349-353. doi:10.1001/archopht.1994.01090150079027

Objective:  To compare the differences in optic disc configuration with different stages of visual field loss in normal-tension glaucoma.

Design:  Interocular pairwise comparisons.

Setting:  Glaucoma clinic of a teaching hospital.

Patients:  Thirteen patients with normal-tension glaucoma and asymmetric visual field loss of at least 2.5 dB in the mean defect of the visual field indexes.

Interventions:  Areas under the optic disc profiles mapped from values for radial sections of the optic disc measured at intervals of 30° and expressed as percentages of the area of a rectangle were obtained from stereophotographs with a computerized image analysis system. Visual fields were tested with automated perimetry (OCTOPUS), using program G1.

Main Outcome Measure:  Correlation analyses between the interocular differences in the areas under the optic disc profile and the interocular differences in the visual field indexes.

Results:  The correlation coefficients between the interocular differences in mean defect and those of the area under the optic disc profile in the superior to temporal sections ranged from −.71 to −.61 (.007<P<.028). The interocular differences in loss variance correlated with the differences in the area under the optic disc profile in the superior section (r=−.61, P=.0252).

Conclusion:  The differences in visual field loss between the two eyes in normal-tension glaucoma appear mainly to reflect morphometric changes in the superior half of the optic disc.

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