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March 1994

Correlation of Asymmetry of Visual Field Loss With Optic Disc Topography in Normal-Tension Glaucoma

Arch Ophthalmol. 1994;112(3):349-353. doi:10.1001/archopht.1994.01090150079027

Objective:  To compare the differences in optic disc configuration with different stages of visual field loss in normal-tension glaucoma.

Design:  Interocular pairwise comparisons.

Setting:  Glaucoma clinic of a teaching hospital.

Patients:  Thirteen patients with normal-tension glaucoma and asymmetric visual field loss of at least 2.5 dB in the mean defect of the visual field indexes.

Interventions:  Areas under the optic disc profiles mapped from values for radial sections of the optic disc measured at intervals of 30° and expressed as percentages of the area of a rectangle were obtained from stereophotographs with a computerized image analysis system. Visual fields were tested with automated perimetry (OCTOPUS), using program G1.

Main Outcome Measure:  Correlation analyses between the interocular differences in the areas under the optic disc profile and the interocular differences in the visual field indexes.

Results:  The correlation coefficients between the interocular differences in mean defect and those of the area under the optic disc profile in the superior to temporal sections ranged from −.71 to −.61 (.007<P<.028). The interocular differences in loss variance correlated with the differences in the area under the optic disc profile in the superior section (r=−.61, P=.0252).

Conclusion:  The differences in visual field loss between the two eyes in normal-tension glaucoma appear mainly to reflect morphometric changes in the superior half of the optic disc.