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August 1994

Experimental Vitreous Replacement With Perfluorotri-n-Propylamine

Author Affiliations

From the Departments of Ophthalmology (Drs Bryan, Friedman, Mames, and Margo) and Pathology (Dr Margo), the University of Florida College of Medicine, Gainesville. Dr Mames has a proprietary interest in perfluorotri-n-propylamine. The other authors do not have any commercial or proprietary interest in perfluorotri-n-propylamine or Alpha Theraupetic Corp, Los Angeles, Calif.

Arch Ophthalmol. 1994;112(8):1098-1102. doi:10.1001/archopht.1994.01090200104030

Objective:  To evaluate perfluorotri-n-propylamine, a perfluorocarbon oil, as a temporary vitreous replacement in rabbits.

Methods:  After undergoing gas compression vitrectomy, rabbits were injected with perfluorotri-n-propylamine for 24 hours or 2 weeks. The rabbits were evaluated clinically and with electroretinography. The globes were then enucleated and processed for histological evaluation.

Results:  Clinical results showed droplet dispersion in the 2-week but not in the 24-hour group. Histological evaluation showed no changes in the retinal pigment epithelium or photoreceptor outer segments. Foam cells were seen in the 2-week but not in the 24-hour group. There was a marked dampening of the electroretinographic response that normalized after the removal of the oil.

Conclusions:  Perfluorotri-n-propylamine demonstrated no retinal toxic side effects in rabbits and is a promising liquid perfluorocarbon oil.