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September 1994

Regression of Limbal Epithelial Dysplasia With Topical Interferon

Author Affiliations

Tampa, Fla

Arch Ophthalmol. 1994;112(9):1145-1146. doi:10.1001/archopht.1994.01090210029007

Limbal epithelial dysplasia may occasionally recur after excision with cryotherapy. The case described below demonstrates a potentially useful topical therapy for these lesions.

Report of a Case.  A 55-year-old woman with a history of prolonged daily sun exposure since childhood presented with a 5-year history of a slowly enlarging mass of the left eye. She complained of a mild, fleeting, stabbing sensation in this eye. There was no change in her vision. Seven years earlier, she underwent a chemical facial peel and was treated with fluorouracil three times a day for 5 weeks and tretinoin for multiple precancerous actinic lesions. Six years before presentation, a diagnosis of cutaneous Merkel cell lymphoma with positive inguinal and retroperitoneal lymph nodes was made. The patient received chemotherapy and radiation treatment without recurrence. She was born and reared in Georgia and moved to Florida at age 32 years.The patient's visual acuity was 20/20