The fascinating article by Klein et al1 reporting that estrogens were associated with a protective effect against lens opacity reminded me of a strange (and unpublished) result from a case-control study by myself and colleagues that was carried out in Oxford, England.2 In that study, we compared 423 patients aged 50 to 79 years with cataracts who were admitted to the Oxford Eye Hospital with 608 controls in the same age range recruited from other hospitals and from the age-sex registers of local general practitioners. This analysis included only data on the 639 women in the study. We asked a general question on drugs that were taken regularly for at least 4 months with a follow-up question that asked specifically about the contraceptive pill. During analysis we looked at total steroids as a risk factor but also identified all subjects who reported the use of contraceptive pills or
Harding JJ. Estrogens and Cataract. Arch Ophthalmol. 1994;112(12):1511. doi:10.1001/archopht.1994.01090240017008
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