We appreciate and respect many of the points raised in the letter by Dr Macek but found her views to lack a broad-based perspective of biology and the nature of clinical inquiry. Dr Macek has the conviction that we can gain truly meaningful information about human disease only from studies in humans. This view ignores the common biologic matrix shared by the myriad organisms that co-evolved, and the great similarities in ocular structure and function found across all vertebrate lines. The vertebrate eye appears fully developed in the fossil record and its basic design has remained essentially unchanged through the millennia.All clinical investigators would agree that data generated from large, well-controlled human clinical trials would be the most effective approach for evaluating the efficacy of a specific therapy for the treatment of a specific human disease. The cost of properly performing such trials is enormous, however, and
Kaufman PL, Murphy CJ. Genetic Studies With Animals-Reply. Arch Ophthalmol. 1995;113(2):139. doi:10.1001/archopht.1995.01100020016012
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