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February 1995

Stromal Healing Following Explantation of an ICR (Intrastromal Corneal Ring) From a Nonfunctional Human Eye

Author Affiliations

From the Anheuser-Busch Eye Institute, the Department of Ophthalmology (Drs Quantock, Kincaid, and Schanzlin), and the Department of Pathology (Dr Kincaid), St Louis (Mo) University School of Medicine. The authors attest that they have no commercial or proprietary interest in KeraVision, Inc, Fremont, Calif, or in the research and materials presented in this article. Dr Schanzlin is a paid consultant for KeraVision, Inc.

Arch Ophthalmol. 1995;113(2):208-209. doi:10.1001/archopht.1995.01100020092036

We examined the cornea of the nonfunctional left eye of a 46-year-old man, which was enucleated 8 months following explantation of an ICR (Intrastromal Corneal Ring). Corneal haze was confined to the midstroma, in the region of the tissue from which the ICR had been removed. Stromal tissue in this area was subtly compressed and irregular. Electron microscopy in conjunction with cuprolinic blue staining demonstrated an unremarkable proteoglycan population and several areas of slight collagen disruption at midstromal depth at the site of the previously implanted ICR. We conclude that disruptions of the corneal stroma that remain 8 months following explantation of an ICR are minimal.

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