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March 1995

Optical Coherence Tomography of the Human Retina

Arch Ophthalmol. 1995;113(3):325-332. doi:10.1001/archopht.1995.01100030081025

Objective:  To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution.

Design:  Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects.

Setting:  Research laboratory.

Participants:  Convenience sample of normal human subjects.

Main Outcome Measures:  Correlation of optical coherence retinal tomographs with known normal retinal anatomy.

Results:  Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-μm depth resolution.

Conclusion:  Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.