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May 1995

Laser Photocoagulation of Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration-Reply

Author Affiliations

New York, NY

Arch Ophthalmol. 1995;113(5):554. doi:10.1001/archopht.1995.01100050016008

In reply  I thank Dr Hawkins for his most cordial and pertinent comments regarding my Editorial.1 Dr Hawkins was concerned that there might be a motivation on the part of the patients in the treated group for a better response to vision testing, and he wondered about the possibility of a sham form of therapy in the nontreated group to control for that possible effect. Given the ethical and administrative limitations and impracticalities of such therapy, given the unavailability of relevant motivational research to predict the possibility of bias in the treated vs the nontreated groups, and given the meticulous experimental design of the MPS, which included randomization, prospectivity, independent masked review, an elite core of clinical investigators, and a comparable prominent group composing the data and safety monitoring committees, I answer Dr Hawkins' question regarding to sham or not to sham by replying simply that there was, in

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