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May 1995

Does the Melanin Content of Uveal Malignant Melanomas Correlate With Their Magnetic Resonance Imaging Appearance?

Author Affiliations

London, England

Arch Ophthalmol. 1995;113(5):555-556. doi:10.1001/archopht.1995.01100050017011

We would like to comment on the article by De Potter et al1 that was published in the March 1994 issue of the Archives. In this article, the authors reported that 41 of 43 uveal melanomas had the "characteristic" magnetic resonance imaging (MRI) appearance of hyperintensity on T1-weighted images and hypointensity on T2-weighted images. They also reported that the degree of tumor pigmentation was not significantly related to the signal intensity of the tumors on unenhanced T1-weighted images, although correlation between tumor pigmentation and signal intensity on T2-weighted images was not investigated. They concluded that factors other than melanin content may be responsible for the MRI features of these tumors.

Although we agree that the majority of uveal melanomas exhibit this MRI appearance, not all series have reported such a preponderance of tumors exhibiting hyperintensity on T1 -weighted images and

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