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May 1995

Effect of Mitomycin C and Fluorouracil-Supplemented Trabeculectomies on the Anterior Segment

Author Affiliations

From the Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary (Drs Dreyer and Chaturvedi), and Research Computing and Biostatistics, Children's Hospital (Dr Zurakowski), Harvard Medical School, Boston, Mass.

Arch Ophthalmol. 1995;113(5):578-580. doi:10.1001/archopht.1995.01100050044028

Objectives:  To determine whether there is increased risk to the corneal endothelium when mitomycin C is used in trabeculectomy surgery instead of fluorouracil, and whether these agents play a role in accelerating cataract formation.

Design, Settings, and Participants:  We analyzed the corneal endothelium and the lens preoperatively and post-operatively in 30 eyes of 21 patients who underwent either a fluorouracil- or mitomycin C-supplemented trabeculectomy.

Results:  No significant differences were found between these two groups in the rate of cataract progression, magnitude of endothelial cell loss, or appearance of endothelial cell morphologic characteristics. Endothelial cell loss accounted for approximately 7% to 8% of the preoperative counts in both groups. In addition, four (27%) of 15 eyes in each group showed evidence of cataract progression as graded by the Lens Opacities Classification System II.

Conclusion:  Fluorouracil- and mitomycin C-supplemented trabeculectomies cause similar changes in the lens and corneal endothelium.