In the July 1994 issue of the Archives, an excellent article by Carones et al1 provided rigorous information regarding the changes in the human corneal endothelium observed 3 and 12 months after myopic photorefractive keratectomy. Four findings of key importance for the present and future of excimer laser photorefractive surgery were reported: (1) postoperatively, the average endothelial densities and morphologic features not only did not deteriorate but even improved in the case of the coefficient of variation of cell area and the percentage of hexagonality; (2) the latter were, in our opinion, correctly attributed in part to the cessation of contact lens use; (3) however, 14 (18.4%) of a total of 76 eyes studied were found to have developed an endothelial cell loss of greater than 5%, the largest loss being 16.2% at the 1-year examination; and (4) this substantial cell loss did not appear to be related to
Maldonado MJ, Menezo JL. The Corneal Endothelium and Myopic Excimer Laser Photorefractive Keratectomy. Arch Ophthalmol. 1995;113(6):697. doi:10.1001/archopht.1995.01100060019005
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