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June 1995

Choroidal Hyperpermeability in Central Serous Choroidopathy: A New Concept?

Author Affiliations

New Orleans, La

Arch Ophthalmol. 1995;113(6):701-702. doi:10.1001/archopht.1995.01100060023012

In the article in the August 1994 issue of the Archives, Guyer et al1 reported on hyperpermeability of the choroid around the site of the dye leakage and elsewhere, undetectable clinically or by fluorescein angiography. They hypothesize that the pathogenesis of the central serous choroidopathy relates to abnormalities (hyperpermeability) of the choroidal vasculature.

Abnormalities of the choroid and their relationship to central serous choroidopathy could not be explained if permeability and the diffusion process across various structures of the retina and choroid had not been established. At the Jules Stein Eye Institute, Los Angeles, Calif, along with others, I evaluated the diffusion processes in the normal and photocoagulated retina, using peroxidase as a tracer material.2-5 This information was significant in explaining excessive transudation in serous choroidopathy, accumulation of fluid under the sensory retina, and the effect of photocoagulation in treating this condition. Our studies demonstrated the following: (1)