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June 1995

A Comparison of Topical Diclofenac With Prednisolone for Postcataract Inflammation

Author Affiliations

From the Cornell University Medical College, New York, NY. The authors have no commercial or proprietary interest in any of the drugs discussed in this article. Dr Roberts serves on the CIBA Vision Ophthalmics Physician Advisory Panel.

Arch Ophthalmol. 1995;113(6):725-727. doi:10.1001/archopht.1995.01100060051031

Objective:  To compare diclofenac sodium with prednisolone acetate for the control of postoperative inflammation after cataract surgery.

Design:  Fifty-two patients undergoing phacoemulsification with posterior chamber intraocular lens implantation were randomly assigned to receive either 0.1% diclofenac eye drops or 1% prednisolone eye drops as their postoperative anti-inflammatory medication. The patients were examined 1 day (baseline), 1 week, and 1 month after surgery. Postoperative inflammation was evaluated subjectively by slit-lamp assessment of cell and flare and objectively by measurement of cell and flare with a laser cell and flare meter.

Results:  At each visit, there was no statistically significant difference in postoperative inflammation either by slit-lamp assessment or with the laser cell and flare meter for the two treatment groups.

Conclusion:  In the dosage used, diclofenac was as effective an anti-inflammatory agent for uncomplicated postcataract inflammation as prednisolone.

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