In a recent correlation of ocular echography and bacterial endophthalmitis, Dr Dacey and colleagues1 found that clear vitreous on initial echography was associated with early streptococcal or culture-negative endophthalmitis. Yet, they also documented the most severe vitreal inflammation and membrane formation in eyes with advanced streptococcal endophthalmitis. The most likely explanation for these apparently disparate findings is that they occurred in eyes with infected blebs. In such cases, streptococci are a prime pathogen. The clinical picture can be explained by an infection that initially spares and then spreads to the vitreous.