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September 1995

Peripheral Thrombolytic Therapy for Central Retinal Artery Occlusion

Author Affiliations

Gainesville, Fla

Arch Ophthalmol. 1995;113(9):1094. doi:10.1001/archopht.1995.01100090016007

We believe that any major improvement in the prognosis for central retinal artery occlusion (CRAO) will need to involve reversal of the intravascular disease process occurring at the site of occlusion. Regional thrombolytic therapy for acute CRAO using catheterization of the ophthalmic artery has shown promising results.1-4 If thrombolytic therapy is to have a positive impact on patient care, however, it must be easy to administer, since accessibility is an important factor in treating this ocular emergency. We describe the results of a pilot study involving three consecutive patients with acute CRAO who were treated with systemic thrombolytic agents. The study was approved by our hospitals' institutional review boards.

Thrombolytic therapy was offered only to patients with acute CRAO whose occlusive event occurred within the previous 6 hours and for whom conventional treatment modalities (ocular massage, anterior chamber paracentesis, rebreathing bag, sublingual nitroglycerin, and topical medication to lower intraocular