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September 1995

Bilateral Central Retinal Vein Occlusions in a Patient With Acquired Immunodeficiency Syndrome: Clinicopathologic Correlation

Author Affiliations

From the Vitreous and Retina Consultants, Winter Haven, Fla (Dr Friedman); and the Departments of Ophthalmology and Pathology, University of South Florida Colleqe of Medicine, Tampa (Dr Margo).

Arch Ophthalmol. 1995;113(9):1184-1188. doi:10.1001/archopht.1995.01100090110031

Four patients with human immunodeficiency virus (HIV) infection and central retinal vein occlusion have been previously described in the literature. The pathologic findings in a fifth patient with this association are reported. The histopathologic findings were similar to ischemic central retinal vein occlusion in persons without HIV infections. There was no evidence of HIV in vascular endothelial cells using electron microscopy and in situ hybridization techniques. The failure to identify any structual or direct infectious cause for central retina vein occlusion in this setting suggests that other hemorheologic factors related to HIV infection are probably responsible for the predispostion to vascular thrombosis.

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