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October 1995

Ocular Lymphoma Diagnosed by Internal Subretinal Pigment Epithelium Biopsy

Author Affiliations

Tampa, Fla

Arch Ophthalmol. 1995;113(10):1233-1234. doi:10.1001/archopht.1995.01100100021014

Vitrectomy and choroidal biopsy have been used to diagnose ocular lymphoma.1,2 Histopathologic confirmation can be difficult, however, because neoplastic lymphocytes may be sequestered between the retinal pigment epithelium (RPE) and Bruch's membrane where they are not easily accessible to biopsy. We describe a 58-year-old man with ocular lymphoma whose diagnosis was established by harvesting cells beneath the RPE via a retinotomy.

Report of a Case.  A 58-year-old man was seen for a 5-month history of painless visual loss in his right eye. He had been treated unsuccessfully for presumed toxoplasmosis retinochoroiditis for 4 months. On examination, the corrected visual acuity was light perception in the right eye and 20/25 OS. A relative afferent defect was present on the right. Dilated funduscopic evaluation of the right eye revealed moderate vitreous cells and yellow-white, irregularly shaped subretinal infiltrates along the major arcades (Figure 1 ). The left fundus was normal. B-scan ultrasonography revealed

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