[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.204.186.91. Please contact the publisher to request reinstatement.
Article
October 1995

Effect of Intravitreal Dexamethasone in Treatment of Pneumococcal Endophthalmitis in Rabbits

Author Affiliations

From the Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas (Dr Park); Retina Service (Drs Park, Samiy, and D'Amico) and Infectious Disease Service (Dr Baker), Massachusetts Eye and Ear Infirmary, Boston; Departments of Ophthalmology (Drs Park, Samiy, and D'Amico), Medicine (Dr Baker), and Microbiology and Molecular Genetics (Dr Ruoff), Harvard Medical School, Boston; and Clinical Microbiology Laboratory, Massachusetts General Hospital, Boston (Dr Ruoff).

Arch Ophthalmol. 1995;113(10):1324-1329. doi:10.1001/archopht.1995.01100100112040
Abstract

Purpose:  To investigate whether corticosteroid therapy would decrease the inflammation and tissue damage associated with pneumococcal endophthalmitis.

Methods:  Albino rabbits were injected intravitreally with 1000 live organisms of Streptococcus pneumoniae and randomized after 24 hours to treatment with intravitreal vancomycin hydrochloride alone (n=10), combination intravitreal vancomycin and intravitreal dexamethasone (n=10), or no treatment (n=10). After 2 weeks, the eyes were examined clinically and enucleated for histopathologic examination.

Results:  Eyes treated with vancomycin and dexamethasone had significantly less intraocular inflammation and more preservation of retinal tissue than untreated eyes or eyes treated with vancomycin alone (P<.05, Fisher's exact test). Untreated and vancomycin-treated eyes were indistinguishable on clinical and histologic examination. Marked anterior and posterior segment inflammation with total retinal necrosis was noted in eyes from both groups.

Conclusion:  Intravitreal corticosteroid therapy may play an important role in minimizing the inflammation and tissue damage associated with pneumococcal endophthalmitis.

×