[Skip to Navigation]
November 1995

Radiotherapy for Thyroid Orbitopathy: Effects on Extraocular Muscle Balance

Author Affiliations

From the Department of Ophthalmology, University of Colorado Health Sciences Center, Denver (Dr Wilson).; Dr Prochoda is in private practice in Loveland, Colo.

Arch Ophthalmol. 1995;113(11):1420-1425. doi:10.1001/archopht.1995.01100110080029

Objective:  To investigate the effects of radiotherapy on the restrictive ophthalmopathy and strabismus that occur with Graves' orbitopathy.

Design:  A prospective study of patients with motility disturbances due to thyroid orbitopathy, followed by serial quantitative measurements of ocular restrictions and deviations, both before and at 1 and 6 months after treatment with high-energy radiotherapy.

Setting:  Urban subspecialty private practice.

Patients:  Thirty-three consecutive patients with restricted extraocular movements and diplopia secondary to thyroid orbitopathy who were treated with radiotherapy were seen during an 8-year period.

Measures:  Maximal horizontal and vertical ductions, plus ocular deviations in primary and reading positions of gaze, were quantitatively evaluated by one clinical investigator to ensure consistency.

Results:  Statistically significant improvement in gaze restriction on supraduction and improvement of vertical and horizontal strabismus were demonstrated at follow-up visits after treatment.

Conclusions:  Although statistically significant improvement of motility disturbances were demonstrated after radiotherapy, there was less than desirable functional improvement of restrictive ophthalmopathy and strabismus; thus the usefulness of radiotherapy was limited when it was used alone to treat diplopia.

Add or change institution