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March 1996

Therapy With Botulinum Toxin

Author Affiliations

Richmond, Va

Arch Ophthalmol. 1996;114(3):358. doi:10.1001/archopht.1996.01100130354031

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This book furnishes a competent source of broad information on botulinum toxin. The basic science section contains the major contribution, providing an orderly summary of knowledge gained from previous investigations. It is formatted so the reader can get a good grasp of what is known about the microscopic, biochemical, and physiologic effects of botulinum toxin on muscular and nervous tissue. The basic science section cites many valuable contributions related to skeletal muscle, but contains few references to publications dealing with the effect of botulinum toxin on extraocular muscle. As a consequence, the functional and histologic distinction between skeletal and extraocular muscle is not clear. The singular point that botulinum toxin has a permanent effect on extraocular muscle and a transient effect on skeletal muscle is without emphasis, and this is of critical importance in distinguishing the therapeutic effects of botulinum toxin between strabismus and "other" disorders.

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