We thank Dr Baker and colleagues for their attention to our article and would like to make the following points in response:• Although enrolling patients only after their bacterial culture status was known would have simplified the conduct of the study, withholding treatment of active bacterial keratitis until laboratory results were available would not have been medically prudent.• Random allocation of patients to either treatment group was employed. Every patient had an equal chance of receiving ofloxacin or the fortified antibiotics.• The subgroup of patients analyzed (those with a positive bacterial culture) was defined prior to the beginning of the study and was the subgroup of interest for evaluating efficacy. Determination of culture status was performed without knowledge of the patient's treatment assignment or clinical outcome. Thus, the comparison of treatment groups within the subgroup of patients with a positive culture is unbiased.1•
O'Brien TP, Maguire MG, Cheetham JK. Efficacy of Ofloxacin vs Cefazolin and Tobramycin in the Therapy for Bacterial Keratitis-Reply. Arch Ophthalmol. 1996;114(5):632–633. doi:10.1001/archopht.1996.01100130624032
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