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July 1996

Long-term, Successful Maintenance of Bilateral Cytomegalovirus Retinitis Using Exclusively Local Therapy

Author Affiliations

Boston, Mass
Miami, Fla
Seattle, Wash

Arch Ophthalmol. 1996;114(7):881-882. doi:10.1001/archopht.1996.01100140095021

A sustained-release, intravitreal implant that supplies ganciclovir directly into the vitreous cavity at a constant rate for approximately 8 months is being tested.1,2 We report the use of multiple ganciclovir implants for the long-term (>3 years) maintenance of cytomegalovirus (CMV) retinitis. Excellent local CMV retinitis control was achieved, even when follow-up exceeded 3 years.

Report of a Case.  In late December 1991, a 33-year-old man with acquired immunodeficiency syndrome was examined; unilateral, peripheral CMV retinitis was diagnosed in the right eye. His visual acuity was 20/20 OU. The CD4 count was 0.003×109L.After administration of intravenous ganciclovir sodium (390 mg), given twice daily for 2 weeks, a positive clinical response was noted (Figure 1). The patient underwent ganciclovir implantation on January 29, 1992; a modification of a previously reported technique was used.2 The administration of intravenous ganiclovir was discontinued on the day of the implantation. By 4 weeks after implantation,

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