A sustained-release, intravitreal implant that supplies ganciclovir directly into the vitreous cavity at a constant rate for approximately 8 months is being tested.1,2 We report the use of multiple ganciclovir implants for the long-term (>3 years) maintenance of cytomegalovirus (CMV) retinitis. Excellent local CMV retinitis control was achieved, even when follow-up exceeded 3 years.
Report of a Case.
In late December 1991, a 33-year-old man with acquired immunodeficiency syndrome was examined; unilateral, peripheral CMV retinitis was diagnosed in the right eye. His visual acuity was 20/20 OU. The CD4 count was 0.003×109L.After administration of intravenous ganciclovir sodium (390 mg), given twice daily for 2 weeks, a positive clinical response was noted (Figure 1). The patient underwent ganciclovir implantation on January 29, 1992; a modification of a previously reported technique was used.2 The administration of intravenous ganiclovir was discontinued on the day of the implantation. By 4 weeks after implantation,