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August 1996

Disordered Meibomian Gland Function in Pseudohypoaldosteronism

Author Affiliations

Birmingham, England; Glasgow, Scotland

Arch Ophthalmol. 1996;114(8):1018-1019. doi:10.1001/archopht.1996.01100140226025

Several diseases cause a salt-wasting state during infancy, notably with severe diarrhea, endocrine abnormalities (such as congenital adrenal hyperplasia), renal disease, and cystic fibrosis.1 However, none are associated with a specific eye abnormality. Pseudohypoaldosteronism (PHA) is characterized by salt wasting with hyponatremia and hyperkalemia in the presence of elevated serum aldosterone levels.2 We report a unique eyelid abnormality resulting from PHA, which may be a valuable clue to the presence of a life-threatening disease, the diagnosis of which can only be made following complex biochemical investigation.

Report of a Case.  A full-term, 5-day-old male neonate was admitted to the special care baby unit with a white discharge from the eyes and vesicular rash on the scalp and trunk. A row of 0.5-mm white toothlike projections were noted on the margin of all 4 eyelids (Figure 1), consisting of solid columns of white material that were visible within and

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